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Analyzing COVID-19 Deaths by Weekday: A Four-Year Statistical Review (2020–2023)

Background. Earlier studies have suggested that the mortality rate of Coronavirus Disease-2019 (COVID-19) may vary by day of the week, possibly due to variations in healthcare system workflows or reporting delays. This study aimed to assess whether such day-of-week effects exist in COVID-19 death data from 2020 to 2023 in the United States. Materials and Methods. We extracted nationwide United States COVID-19 mortality data from the Centers for Disease Control and Prevention WONDER database,...

Video-EEG polygraphy in the clinical characterization of hyperkinetic movement disorders: a tertiary referral cohort

Background: Hyperkinetic movement disorders (MDs) in children, including tremor, myoclonus, dystonia, chorea, and tics, often present with overlapping or evolving clinical features, making classification based on observation alone challenging. Neurophysiological techniques such as video-EEG polymyography (P-VEEG) and somatosensory evoked potentials (SEPs) may provide objective markers to improve diagnostic accuracy, yet their application in pediatric populations remains limited. Objective: To...

AFG2A-related encephalopathy, expanding the neurodevelopmental and epileptic spectrum

Objectives To expand the clinical features, epilepsy phenotype, and genotype in individuals with AFG2A-related encephalopathy (AFG2A-RE), previously known SPATA5-related encephalopathy, and to explore potential associations between genotype and epilepsy manifestations. Methods We conducted a systematic literature review focusing on AFG2A-RE publications (45 patients), also included 6 of our patients recently reported as the result of a multicentre, retrospective, observational, and descriptiv...

Severe aortic stenosis: secular trends of incidence and outcomes

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«L’utero, viscere pensante». Giacomo Casanova e la polemica medicale sull’inferiorità biologica femminile a Bologna nel secondo Settecento

Il contributo ricostruisce una polemica medicale diffusa a Bologna nel 1772. Tale polemica vide la partecipazione di due anonimi anatomisti delle Università di Bologna e di Ferrara. Coda tardo settecentesca dell’antica querelle des femmes, essa riguardava la ricerca di una causa fisica a spiegazione della pretesa diversità di pensiero e di comportamento delle donne. Una diversità che era valutata in sostanza come inferiorità, fatta derivare dalla presenza dell’utero nel corpo femminile. Nella...

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