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Bilirubin and migraine: Critical review of the literature

The many and multifaceted metabolic functions of bilirubin, the final product of heme metabolism, are still not completely understood. Several lines of evidence now attest that this molecule may produce both toxic and protective effects depending on its blood concentration. More specifically, lower values of total bilirubin in serum or plasma have been linked with an increased risk of developing cardiovascular disease (5), pulmonary embolism (6) and many other severe and prevalent human disea...

Establishing the upper reference limit of Galectin-3 in healthy blood donors

Introduction: Galectin-3 (Gal-3) is an independent predictor of poor outcomes and mortality in patients with heart failure (HF). Thus, it has been proposed as a reliable prognostic biomarker for HF. The definition of reference intervals is mandatory for interpreting the findings of experimental studies and encouraging the routine use of biomarkers in clinical practice. To date, no study assessed the reference intervals of Gal-3 and identified the biological variables that affect its concentra...

TRAP1 ablation improves mitochondrial cristae and oxidative phosphorylation in pancreatic cancer stem cells

Aim: Cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) display high metabolic plasticity, supporting tumor aggressiveness and therapeutic resistance. Here, we investigated the role of the mitochondrial chaperone TRAP1 in regulating mitochondrial architecture, metabolism, and adhesion in CSCs. Methods: We studied an in vitro model of CSCs using Panc1 cells and the corresponding stable TRAP1-knockout cells (TRAP1-KO). Molecular techniques used were quantitative polymerase chai...

Risk of obstructive sleep apnea among healthcare workers: a systematic review and meta-analysis

: Obstructive sleep apnea (OSA) is a very common but underdiagnosed health disorder. OSA-derived cognitive disorders could increase the risk of work-related injuries among healthcare workers (HW), representing a major threat both to them and their patients. This study aimed to conduct a systematic review and meta-analysis to assess the relevance of OSA in the healthcare sector. Studies reporting the prevalence of either high risk of OSA (HRO) or diagnosed OSA, assessed respectively by structu...

Cancer Risk After Initial Surveillance of Intraductal Papillary Mucinous Neoplasms (IPMNs): Are We Missing the Window for Prevention?

Background: The management of intraductal papillary mucinous neoplasms (IPMNs) has evolved through successive International Association of Pancreatology guidelines, aiming to refine surgical indications and improve cancer prevention. With broader adoption of surveillance, the oncologic outcomes of patients resected after follow-up-and the effectiveness of current strategies in preventing malignancy-remain unclear. This study examined how evolving management has influenced surgical selection a...

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