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Exercise reveals precocious-subclinical cardiovascular and muscular dysfunction in transfusion dependent beta-thalassemia (TDT) patients without cardiac iron overload

Background: Transfusion-dependent β-thalassemia (TDT) is characterized by reduced exercise capacity due to chronic hemolytic anemia, iron overload cardiomyopathy, and potential skeletal muscle alterations. Early cardiovascular and muscular dysfunction in the absence of cardiac iron overload remains poorly characterized. Methods: In this exploratory study, 9 TDT patients without cardiac iron overload and with normal body mass index (BMI) were matched with 9 healthy controls. Cardiopulmonary ex...

Levodopa-induced dyskinesia is associated with worse gait and balance in Parkinson's disease

Levodopa-induced dyskinesia (LID) is a major source of disability in advanced Parkinson's disease (PD), whose impact on gait and balance across medication states still remains unclear. We aimed to compare gait and balance performance between comparable dyskinetic (Dysk-matched) and non-dyskinetic (No-Dysk) PD patients in OFF and ON state, and to explore neural correlates using structural and resting-state functional MRI (rs-fMRI). PD patients were consecutively enrolled among candidates for d...

Affiliate stigma among family caregivers of people with mental disorders: results from a national survey in Italy

Purpose: Affiliate stigma-the internalization of public stigma by family caregivers of people with mental disorders-has been associated with emotional distress, burden, and reduced well-being. However, evidence from European contexts remains limited, and no national studies have been conducted in Italy. This study aimed to (1) assess levels of affiliate stigma among Italian family caregivers and (2) identify sociodemographic, relational, and psychological determinants of stigma. Methods: A cr...

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing-Remitting Multiple Sclerosis

Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty-seven early relapsing-remitting MS patients were enrolled at diagnosis and followed longitudinally. PRLs and CP volume were evaluated at diagnosis using 3 T-MRI. Cognitive decline over time was classified as cognitive progression independent of relapse/MRI activity (PIRMA). Fifty-five patients (63.2%) showed m...

In Vitro Evaluation of Mechanical Fat Processing Devices: Impact on Adipocytes and Adipose-Derived Stem Cells

In the fat grafting procedure, the new European Regulations and the necessity to perform minimal manipulation processing require the verification of security and performance levels of each device and, in this particular context, functional and tissue responses. The aim of this study is to evaluate the integrity of adipocytes and adipose-derived stromal/stem cells (ADSCs) after their processing using two new mechanical devices operating with a closed system. In this study, two new fat processi...

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