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Interventions to prevent sexual harassment in universities: an umbrella review of systematic reviews

Objective This umbrella review analyzes existing literature on sexual harassment (SH) prevention in universities, including approaches that address SH within broader gender-based violence (GBV) forms. Conducted as part of the Uni4Equity project (CERV-2022-DAPHNE Programme), it aims to identify key trends, limitations and gaps in current prevention strategies.Method A systematic search of four databases (PubMed, Scopus, Web of Science, and PsycINFO) was conducted to identify relevant systemati...

Burdock (Arctium lappa L.) Root Extract Induces Transcriptional Signatures Associated with Metal Homeostasis and Lipid Metabolism in Human Keratinocytes

Background/Objectives: Botanical metabolites can modulate cellular stress responses, lipid homeostasis, and epithelial organization. Arctium lappa L. (Burdock) root contains bioactive phytochemicals and inulin-type fructans, but its molecular effects in vitro remain incompletely characterized. Methods: HaCaT keratinocytes were exposed to a standardized aqueous Burdock root extract (1 mg/mL) for 4.5 h and analyzed by RNA sequencing. The Burdock-versus-control response was evaluated using gene-...

Prevalence of alpha-synuclein seeding activity in the Olfactory Mucosa following SARS-CoV-2 infection: results from a pilot study

Olfactory dysfunction (OD) is a hallmark of SARS-CoV-2-infection where it is believed to result from neuroinflammation induced by viral invasion via the olfactory mucosa (OM). Hyposmia also affects the majority of patients with Parkinson's disease (PD) where it is caused by α-synuclein (aSyn) pathology in the olfactory system, and aSyn-seeding-activity can be detected in the OM using aSyn-seeding-amplification-assays (aSyn-SAA). The present pilot study aimed to investigate whether SARS-CoV-2-...

Structural and optical properties of ligand-free noble metal nanoclusters synthesized by ns-pulsed laser ablation at the argon–water interface

Fully inorganic ligand-free noble metal nanoclusters (NCs) are a challenging system to obtain due to the fact that conventional chemical synthesis introduces surface-bound contaminants. Here, we present a one-step method for synthesizing highly pure, photoluminescent gold (Au) and silver (Ag) NCs by using Pulsed Laser Ablation at the argon-water interface to ensure an entirely CO2-free ablation environment. The colloids generated contain a mixture of larger plasmonic nanoparticles and small p...

Uncovering combination therapies for immune- mediated inflammatory diseases through systems biology analysis on longitudinal patient data

While targeted therapies have reshaped the clinical management of immune-mediated inflammatory diseases (IMIDs), primary non-response remains a major obstacle for many patients. Combining two targeted therapies is an emerging strategy to overcome this therapeutic ceiling, but the number of possible drug pairs makes prioritization difficult. For this objective, we present mitigation of non-response signature (MNRS), a computational approach that uses longitudinal blood transcriptomic data from...

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