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Attitudes Toward Adoption by Transgender Adults

This study explored cisgender heterosexual adults’ perceptions of children placed in an adoptive family led by a couple with a transgender partner. Participants (n = 871) read one of five vignettes in which a couple (a cisgender different-gender couple, a cisgender same-gender male couple, a cisgender same-gender female couple, a couple with a female transgender partner, or a couple with a male transgender partner) intended to adopt two children. After reading the vignette, participants rated...

Articles’ retraction during the pandemic: COVID-19 is not the pacemaker

The results of our analysis in Scopus show that articles on COVID-19 (or SARS-CoV-2) have not been retracted more frequently than those involving other common pathologies such as cancer, sepsis, trauma, Alzheimer’s disease and even diabetes. Nonetheless, the trend of article retractions on COVID-19 and/or SARS-CoV-2 has gradually increased between 2020 and 2023, emphasizing that the urgency of publishing new information on the diagnosis and treatment of COVID-19 combined with perhaps too rapi...

Signal management and risk minimization strategy: a case study on obinutuzumab and non-overt disseminated intravascular coagulation

Introduction: In December 2020, the Italian Medicines Agency (AIFA) in collaboration with the Italian Regional Centers of Pharmacovigilance evaluated four individual case safety reports (ICSRs) reporting obinutuzumab and non-overt disseminated intravascular coagulation (DIC) as a new possible signal. In this study, we described the process of signal management for obinutuzumab-associated non-overt DIC. Methods: In accordance with the Guideline on Good Pharmacovigilance Practices Module...

Biosimilars approvals by thirteen regulatory authorities: A cross-national comparison

Biosimilars are biological medicines highly similar to a previously licensed reference product and their licensing is expected to improve access to biological therapies. This study aims to present an overview of biosimilars approval by thirteen regulatory authorities (RA). The study is a cross-national comparison of regulatory decisions involving biosimilars in Argentina, Australia, Brazil, Chile, Canada, Colombia, Europe, Hungary, Guatemala, Italy, Mexico, Peru and United States. We examined...

Potentially inappropriate drug use in myasthenia gravis: a real-world population-based cohort study in Italy

Introduction: To evaluate the use of pyridostigmine in presence of contraindications, and the use of concomitant potentially contraindicated drugs in a cohort of patients affected by Myasthenia Gravis (MG) in the Italian Regions of Lazio, Tuscany, and Umbria. Methods: This is a retrospective cohort study. A multivariate logistic regression model was used to evaluate the determinants of pyridostigmine and of potentially contraindicated drugs use in MG patients. Results: Among 591 inciden...

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