Purpose: To test the correlation between necrosis extent at CT and CA 19.9 serum levels as a possible outcome predictor after radiofrquency ablation (RFA) of unresectable pancreatic adenocarcinomas. Material and Methods: 51 patients with unresectable pancreatic adenocarci- noma were prospectively treated with RFA. CT exam was performed one week after RFA, while CA 19.9 assessment was performed after one month. Per- centage necrosis extent at CT between patients with reduced/stable or in- creased CA 19.9 was compared with t-test. Results: CA 19.9 levels were reduced 1 month after RFA in 26/51 (51%) pa- tients, while were stable in 12/51 (24%). 13 patients (25%) presented increased CA 19.9 levels. Mean percentage necrosis difference between patients with stable or <30% reduced CA 19.9 levels and those with >30% reduced CA 19.9 levels was statistically signi cant (p<0.05). The mean necrosis extent was 43% in patients with >30% CA 19.9 reduction. Conclusion: RFA of unresectable pancreatic adenocarcinoma induces cytore- duction, as showed by CA 19.9 reduction. It seems that the larger is the ablated area, the more consistent is CA 19.9 reduction. To achieve a reduction greater than 30% in CA 19.9 levels, more than 40% of the lesion must be treated.
Cytoreduction after radiofrequency ablation of unresectable pancreatic adenocarcinoma: correlation between CA 19.9 serum levels and necrosis extent at CT
D'ONOFRIO, Mirko;DE ROBERTIS LOMBARDI, Riccardo;MILAZZO, Teresa;GIRELLI, Roberta;PAIELLA, SALVATORE;BASSI, Claudio;PEDERZOLI, Paolo
2015-01-01
Abstract
Purpose: To test the correlation between necrosis extent at CT and CA 19.9 serum levels as a possible outcome predictor after radiofrquency ablation (RFA) of unresectable pancreatic adenocarcinomas. Material and Methods: 51 patients with unresectable pancreatic adenocarci- noma were prospectively treated with RFA. CT exam was performed one week after RFA, while CA 19.9 assessment was performed after one month. Per- centage necrosis extent at CT between patients with reduced/stable or in- creased CA 19.9 was compared with t-test. Results: CA 19.9 levels were reduced 1 month after RFA in 26/51 (51%) pa- tients, while were stable in 12/51 (24%). 13 patients (25%) presented increased CA 19.9 levels. Mean percentage necrosis difference between patients with stable or <30% reduced CA 19.9 levels and those with >30% reduced CA 19.9 levels was statistically signi cant (p<0.05). The mean necrosis extent was 43% in patients with >30% CA 19.9 reduction. Conclusion: RFA of unresectable pancreatic adenocarcinoma induces cytore- duction, as showed by CA 19.9 reduction. It seems that the larger is the ablated area, the more consistent is CA 19.9 reduction. To achieve a reduction greater than 30% in CA 19.9 levels, more than 40% of the lesion must be treated.
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