Purpose: To describe MRI features including diffusion-weighted imaging (DWI) of pancreatic neuroendocrine neoplasms (PanNENs) according to their histo- logical grade. Material and methods: Preoperative MR examinations of 50 PanNEN patients were retrospectively reviewed. Qualitative and quantitative MR features were evaluated by two radiologists. All MR features were compared between histo- logical grades using Chi-square/Fisher’s exact test and Student’s T/ANOVA test. P values <0.05 were considered statistically signi cant. Results: Ill-de ned margins, local in ltration, vascular involvement and liver metastases were signi cantly more common among G2-3 PanNENs com- pared to G1 tumors. G1 tumors were signi cantly smaller than G2-3 tumors (22.8 vs 38.1 mm, p=0.016); the mean ADC value was signi cantly lower among G2-3 tumors as compared to G1 tumors (1.03±0.3 vs 1.38±0.6, p=0.010). Conclusion: MR features of PanNENs vary according to their histological grade; MRI including DWI can differentiate G1 from G2-3 PanNENs.
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