Post-hepatectomy liver failure (PHLF) is the standardized term to define the post-operative acquired deterioration of liver ability to maintain its synthetic, excretory and detoxifying functions (1). The pre-operative assessment of the future liver remnant volume (FLRV), as long as the assessment of liver function, is therefore mandatory to minimize complications. While the FLRV is today easily predictable with imaging methods, first of all with CT, it would seem to be no space for the imaging methods in the evaluation of liver function. Different tests have been used to assess in the most objective manner liver function; among all, particular emphasis was given to the indocyanine green retention test, which serially measures the serum concentration of the indocyanine green, a pigment with exclusive hepato-biliary metabolism and excretion (2). The purpose of this study is to assess the reliability of perfusion CT, which allows to evaluate liver perfusion, a key factor for its function, in the estimation of liver function in patients with hepato-biliary malignancies scheduled for liver resection; the perfusional data were compared with indocyanine green retention test values.

Comparison between CT perfusion and indocyanine green retention test results in the assessment of hepatic function

DE ROBERTIS LOMBARDI, Riccardo;D'ONOFRIO, Mirko;Crosara, Stefano;CANESTRINI, Stefano;PUNTEL, Gino;POZZI MUCELLI, Roberto
2013

Abstract

Post-hepatectomy liver failure (PHLF) is the standardized term to define the post-operative acquired deterioration of liver ability to maintain its synthetic, excretory and detoxifying functions (1). The pre-operative assessment of the future liver remnant volume (FLRV), as long as the assessment of liver function, is therefore mandatory to minimize complications. While the FLRV is today easily predictable with imaging methods, first of all with CT, it would seem to be no space for the imaging methods in the evaluation of liver function. Different tests have been used to assess in the most objective manner liver function; among all, particular emphasis was given to the indocyanine green retention test, which serially measures the serum concentration of the indocyanine green, a pigment with exclusive hepato-biliary metabolism and excretion (2). The purpose of this study is to assess the reliability of perfusion CT, which allows to evaluate liver perfusion, a key factor for its function, in the estimation of liver function in patients with hepato-biliary malignancies scheduled for liver resection; the perfusional data were compared with indocyanine green retention test values.
Abdomen, Liver, CT, Contrast agent-intravenous, Diagnostic procedure, Experimental investigations, Neoplasia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/947905
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