AbstractBackground: Oral lichen planus (OLP) is considered to be an autoimmune diseaseof unknown aetiology that affects the mucosae, especially the oral cavity.Objective: We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointmentfor the treatment of OLP.Patients and Methods: A total of 32 patients (20 females and 12 males; all white,Italian origin, mean age of 43.6 18.4 years; 16 patients per treatment group) weretreated with tacrolimus or clobetasol ointment for 4 weeks in a randomized,double-blind, clinical trial. Pain severity, burning sensation, and mucosal lesionextension were assessed using a four-point scale.Results: At the end of the treatment period, symptom scores were significantly lowerin the tacrolimus group than in the clobetasol group.Conclusion: The results of this study suggest that tacrolimus 0.1% ointment is moreeffective than clobetasol propionate 0.05% ointment in the treatment of OLP.However, other studies are needed to confirm the effectiveness of this treatment beforeit can be recommended for use in clinical practice.

Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus

CORROCHER, Giovanni;MARTINELLI, Nicola;BIASI, Domenico;NOCINI, Pier Francesco;LOMBARDO, Giorgio;FIOR, Andrea;CORROCHER, Roberto;BAMBARA, Lisa Maria;PACOR, Maria Luisa
2008-01-01

Abstract

AbstractBackground: Oral lichen planus (OLP) is considered to be an autoimmune diseaseof unknown aetiology that affects the mucosae, especially the oral cavity.Objective: We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointmentfor the treatment of OLP.Patients and Methods: A total of 32 patients (20 females and 12 males; all white,Italian origin, mean age of 43.6 18.4 years; 16 patients per treatment group) weretreated with tacrolimus or clobetasol ointment for 4 weeks in a randomized,double-blind, clinical trial. Pain severity, burning sensation, and mucosal lesionextension were assessed using a four-point scale.Results: At the end of the treatment period, symptom scores were significantly lowerin the tacrolimus group than in the clobetasol group.Conclusion: The results of this study suggest that tacrolimus 0.1% ointment is moreeffective than clobetasol propionate 0.05% ointment in the treatment of OLP.However, other studies are needed to confirm the effectiveness of this treatment beforeit can be recommended for use in clinical practice.
2008
clobetasol; tacrolimus; oral lichen planus
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/313359
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 75
  • ???jsp.display-item.citation.isi??? 68
social impact