Platelet microparticles are generated from activated platelets and have a role in arterial thromboembolism. Microparticles were isolated from healthy subjects and stimulate with arachidonic acid, ADP, a thrombin analogue, epinephrine or collagen in the presence or absence of ASA, the TP receptor antagonist SQ29548, apyrase and the P2Y12 inhibitor PBS-0739. Both ADP ans thromboxane A2 are required as amplifier of micropaticles shedding. The engagement of either the fibrinogen or the collagen receptor are necessarily implicated in microparticles generation.
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