Platelet microparticles are generated from activated platelets and have a role in arterial thromboembolism. Microparticles were isolated from healthy subjects and stimulate with arachidonic acid, ADP, a thrombin analogue, epinephrine or collagen in the presence or absence of ASA, the TP receptor antagonist SQ29548, apyrase and the P2Y12 inhibitor PBS-0739. Both ADP ans thromboxane A2 are required as amplifier of micropaticles shedding. The engagement of either the fibrinogen or the collagen receptor are necessarily implicated in microparticles generation.

XXIV National Congress of the Italian Society for Thrombosis and Hemostasis - SISET: Abano Terme (PD), Italy 9-12 November 2016

Giacomazzi, Alice;Degan, Maurizio;Calabria Stefano;Meneguzzi, Alessandra;Minuz, Pietro
2016

Abstract

Platelet microparticles are generated from activated platelets and have a role in arterial thromboembolism. Microparticles were isolated from healthy subjects and stimulate with arachidonic acid, ADP, a thrombin analogue, epinephrine or collagen in the presence or absence of ASA, the TP receptor antagonist SQ29548, apyrase and the P2Y12 inhibitor PBS-0739. Both ADP ans thromboxane A2 are required as amplifier of micropaticles shedding. The engagement of either the fibrinogen or the collagen receptor are necessarily implicated in microparticles generation.
microparticles
antiplatelet agents
platelet
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/975525
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