The quadrivalent human papillomavirus (HPV) vaccine contains capsid L1 proteins of HPV-6–11, -16 and -18, and 225 lg of aluminum hydroxyphosphate sulfate as adjuvant to potentiate the immune response.1 Aluminum may rarely induce foreign body reactions, which at times may be severe.2 A 24-year-old woman presented with a 11 cm 9 6 cm indurated plaque on the left deltoid area that developed 4 months after HPV vaccine injection.
Severe cutaneous aluminum reaction to quadrivalent human papillomavirus vaccine treated with cyclosporin
Maurelli M.;Colato C.;Girolomoni G.;Gisondi P.
2017-01-01
Abstract
The quadrivalent human papillomavirus (HPV) vaccine contains capsid L1 proteins of HPV-6–11, -16 and -18, and 225 lg of aluminum hydroxyphosphate sulfate as adjuvant to potentiate the immune response.1 Aluminum may rarely induce foreign body reactions, which at times may be severe.2 A 24-year-old woman presented with a 11 cm 9 6 cm indurated plaque on the left deltoid area that developed 4 months after HPV vaccine injection.
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