Liver Metastases From Renal Oncocytoma With Vascular Extension

Cacciamani, Giovanni; Cima, Luca; Ficial, Miriam; Novella, Giovanni; Siracusano, Salvatore; Tedeschi, Umberto; Balzarro, Matteo; Montin, Umberto; Cerruto, Maria A; De Marco, Vincenzo; Porcaro, Antonio B; Hes, Ondrej; DʼErrico, Antonia; Martignoni, Guido; Ghimenton, Claudio; Zaza, Gianluigi; Artibani, Walter; Brunelli, Matteo; Eccher, Albino

doi:10.1097/PAI.0000000000000490

The 2016 World Health Organization Renal Tumor Classification defines renal oncocytoma (RO) as a benign epithelial tumor; however, malignant histopathologic features have been documented. Rare cases with metastases have been reported. We describe the case of a 62-year-old woman who was referred to the Urology Clinic for a routine work-up. Magnetic resonance imaging and computerized tomography showed a 7-cm mass in the middle and lower portions of the left kidney and 2 suspected liver metastases. The patient underwent surgery. Microscopically both renal and liver lesions presented solid, solid-nested, and microcystic architecture, composed predominantly of large eosinophilic cells without any worrisome pattern except the vascular extension. The cells were positive for S100A1, CD117, and PAX-8 and negative for CAIX, CK7, and AMACR. Fluorescence in situ hybridization showed a disomic profile for the chromosomes 1, 2, 6, 7, 10, 17. No mutation of coding sequence of the SDHB, SDHC, SDHD, VHL, and BHD genes and no loss of heterozygosity at 3p were found. The final diagnosis was “RO” according to the 2016 World Health Organization Renal Tumor Classification with “liver metastases.” This report provides a wide clinical-pathologic, immunophenotypical and molecular documentation of a RO with liver metastases

Titolo:	Liver Metastases From Renal Oncocytoma With Vascular Extension
Autori:	CACCIAMANI, GIOVANNI [Writing – Original Draft Preparation] (Corresponding) CIMA, Luca [Investigation] Ficial, Miriam [Investigation] NOVELLA, GIOVANNI [Membro del Collaboration Group] Siracusano, Salvatore [Membro del Collaboration Group] TEDESCHI, UMBERTO [Membro del Collaboration Group] BALZARRO, Matteo [Membro del Collaboration Group] Montin, Umberto CERRUTO, Maria Angela [Supervision] DE MARCO, VINCENZO [Membro del Collaboration Group] PORCARO, Antonio Benito [Membro del Collaboration Group] Hes, Ondrej DʼErrico, Antonia MARTIGNONI, Guido [Membro del Collaboration Group] GHIMENTON, CLAUDIO [Membro del Collaboration Group] Zaza, Gianluigi [Membro del Collaboration Group] ARTIBANI, Walter [Supervision] BRUNELLI, Matteo [Supervision] ECCHER, Albino [Membro del Collaboration Group] mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2019
Rivista:	APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY
Handle:	http://hdl.handle.net/11562/970217
Appare nelle tipologie:	01.01 Articolo in Rivista

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http://hdl.handle.net/11562/970217

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