Objectives: Ga-68-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT) is recommended in the workup of pancreas neuroendocrine tumors (PanNETs); evidence suggests that F-18-FDG (F) PET/CT can also provide prognostic information. Aims of this study were to assess the role of combined Ga-and F-PET/CT in the evaluation of grade (G) 1-2 PanNETs and to test the correlation between F-PET/CT positivity and tumor grade.Methods: Preoperative Ga-and F-PET/CT of 35 patients with surgically resected G1-2 PanNETs were evaluated. For grading, the 2010 World Health Organization Classification was used; an ancillary analysis with Ki67 cutoffs at 5% to 20% was conducted. Correlation between F-PET/ CT positivity (SUVmax > 3.5) and grade was assessed.Results: Of 35 PanNETs, 28.6% and 71.4% were G1 and G2 as per World Health Organization. Ga-PET/CT showed high sensitivity (94.3%) in detecting G1-2 PanNETs. F-PET/CT was positive in 20% and 76% G1 and G2 tumors (P = 0.002). F-PET/CT identified G2 PanNETs with high positive predictive value (PPV, 90.5%). F-PET/CT correlated with tumor grade also in the ancillary analysis (P = 0.009).Conclusions: The high sensitivity of Ga-PET/CT in NET detection is known. The high PPV of F-PET/CT in the identification of G2 forms suggests its potential role in PanNETs prognostication and risk stratification.

Role of Combined Ga-68-DOTATOC and F-18-FDG Positron Emission Tomography/Computed Tomography in the Diagnostic Workup of Pancreas Neuroendocrine Tumors Implications for Managing Surgical Decisions

CINGARLINI, Sara
;
Ortolani, Silvia;BUTTURINI, Giovanni;Malpaga, Anna;D'ONOFRIO, Mirko;DAVI', Maria Vittoria;VALLERIO, Paola;RUZZENENTE, Andrea;Capelli, Paola;CITTON, ELIA;Grego, Elisabetta;TRENTIN, CHIARA;DE ROBERTIS LOMBARDI, Riccardo;SCARPA, Aldo;BASSI, Claudio;TORTORA, GIAMPAOLO
2017

Abstract

Objectives: Ga-68-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT) is recommended in the workup of pancreas neuroendocrine tumors (PanNETs); evidence suggests that F-18-FDG (F) PET/CT can also provide prognostic information. Aims of this study were to assess the role of combined Ga-and F-PET/CT in the evaluation of grade (G) 1-2 PanNETs and to test the correlation between F-PET/CT positivity and tumor grade.Methods: Preoperative Ga-and F-PET/CT of 35 patients with surgically resected G1-2 PanNETs were evaluated. For grading, the 2010 World Health Organization Classification was used; an ancillary analysis with Ki67 cutoffs at 5% to 20% was conducted. Correlation between F-PET/ CT positivity (SUVmax > 3.5) and grade was assessed.Results: Of 35 PanNETs, 28.6% and 71.4% were G1 and G2 as per World Health Organization. Ga-PET/CT showed high sensitivity (94.3%) in detecting G1-2 PanNETs. F-PET/CT was positive in 20% and 76% G1 and G2 tumors (P = 0.002). F-PET/CT identified G2 PanNETs with high positive predictive value (PPV, 90.5%). F-PET/CT correlated with tumor grade also in the ancillary analysis (P = 0.009).Conclusions: The high sensitivity of Ga-PET/CT in NET detection is known. The high PPV of F-PET/CT in the identification of G2 forms suggests its potential role in PanNETs prognostication and risk stratification.
pancreas neuroendocrine tumors (PanNETs), Ga-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/955133
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