Our study demonstrates that MyD88 signaling in innate myeloid cells plays an important role on disease propagation and exacerbation in the IMQ-induced model of psoriasis. However, MyD88 signaling is dispensable for the initiation of keratinocyte-mediated inflammatory responses.
Distinct role for MyD88 signaling in myeloid cells and stromal cells in an imiquimod-induced mouse model of psoriasis.
Costa, Sara;Marini, Olivia;CASSATELLA, Marco Antonio;GIROLOMONI, Giampiero;SCAPINI, Patrizia
2014-01-01
Abstract
Our study demonstrates that MyD88 signaling in innate myeloid cells plays an important role on disease propagation and exacerbation in the IMQ-induced model of psoriasis. However, MyD88 signaling is dispensable for the initiation of keratinocyte-mediated inflammatory responses.
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