In this study we demonstrate that the reciprocal production of BAFF and IFNg establishes an inflammatory loop between myeloid cells and T cells that exacerbates autoimmunity in the Lyn-deficient model of autoimmunity. Our findings uncover an important pathological role of BAFF in autoimmune disorders.
Myeloid cells, BAFF and IFNg establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
SCAPINI, Patrizia;CASSATELLA, Marco Antonio;
2011-01-01
Abstract
In this study we demonstrate that the reciprocal production of BAFF and IFNg establishes an inflammatory loop between myeloid cells and T cells that exacerbates autoimmunity in the Lyn-deficient model of autoimmunity. Our findings uncover an important pathological role of BAFF in autoimmune disorders.
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