The concept of dose equivalence is important for many purposes. The classical approach published by Davis in 1974 subsequently dominated textbooks for several decades. It was based on the assumption that the mean doses found in flexible-dose trials reflect the average optimum dose which can be used for the calculation of dose equivalence. We are the first to apply the method to second-generation antipsychotics.

Dose Equivalents for Second-Generation Antipsychotic Drugs: The Classical Mean Dose Method

CIPRIANI, Andrea;
2015-01-01

Abstract

The concept of dose equivalence is important for many purposes. The classical approach published by Davis in 1974 subsequently dominated textbooks for several decades. It was based on the assumption that the mean doses found in flexible-dose trials reflect the average optimum dose which can be used for the calculation of dose equivalence. We are the first to apply the method to second-generation antipsychotics.
2015
antipsychotic drugs; dose; equivalence; schizophrenia; Antipsychotic Agents; Humans; Schizophrenia; Drug Dosage Calculations; Randomized Controlled Trials as Topic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/947881
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