In the last years there has been an increasing interest in the mining of biological networks involving miRNAs. Recent works about the function of miRNAs have proved the existence of functional interactions between them and interesting properties which characterize these networks have been deducted. miRScape is the first Cytoscape plugin to mining on biological networks annotated with microRNAs. Cytoscape is a bioinformatics software platform for the visualization and analysis of biological networks. It makes use of a web-based knowledge base called miRo’, which introduce a new layer of associations between genes and phenotypes based on miRNAs annotations. Given a network, previously loaded into Cytoscape, miRScape allows to identify relationships among genes, processes, functions and diseases at the miRNA level and annotate them as attributes of network nodes. These annotated networks may be further analyzed by using mining features available as plug-ins on Cytoscape.

miRScape: A Cytoscape Plugin to Annotate Biological Networks with microRNAs

GIUGNO, ROSALBA;
2009-01-01

Abstract

In the last years there has been an increasing interest in the mining of biological networks involving miRNAs. Recent works about the function of miRNAs have proved the existence of functional interactions between them and interesting properties which characterize these networks have been deducted. miRScape is the first Cytoscape plugin to mining on biological networks annotated with microRNAs. Cytoscape is a bioinformatics software platform for the visualization and analysis of biological networks. It makes use of a web-based knowledge base called miRo’, which introduce a new layer of associations between genes and phenotypes based on miRNAs annotations. Given a network, previously loaded into Cytoscape, miRScape allows to identify relationships among genes, processes, functions and diseases at the miRNA level and annotate them as attributes of network nodes. These annotated networks may be further analyzed by using mining features available as plug-ins on Cytoscape.
2009
978-88-7388-242-8
miRNA, Network
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/940502
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