high copy numbers of IDO mRNA may be a negative independent predicting variable for overall and relapse-free survival in adult AML. Blast cells from a subset of childhood AML express functional IDO1 and restrain IFN-γ secretion by CD8+ T cells, while enhancing IL-4 production by CD4+ T cells. From a therapeutic standpoint, STAT3 inhibitors may effectively interfere with IDO1 expression by AML cells, thus tipping the Th1/Th2 balance in favor of anti-leukemia immune responses.
Indoleamine 2, 3-Dioxygenase-1 (IDO1) Is Expressed by a Subset of Childhood Acute Myeloid Leukemias and Restrains IFN-gamma Production by T Cells
MORETTA, Francesca;
2012-01-01
Abstract
high copy numbers of IDO mRNA may be a negative independent predicting variable for overall and relapse-free survival in adult AML. Blast cells from a subset of childhood AML express functional IDO1 and restrain IFN-γ secretion by CD8+ T cells, while enhancing IL-4 production by CD4+ T cells. From a therapeutic standpoint, STAT3 inhibitors may effectively interfere with IDO1 expression by AML cells, thus tipping the Th1/Th2 balance in favor of anti-leukemia immune responses.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
