Few papers focused on association between hepatolithiasis (HL) and cholangiocarcinoma (CCC) in Western countries. The aims of this paper are to describe the clinical presentation, treatment, and postoperative outcomes of CCC with HL in a cohort of Western patients and to compare the surgical outcomes of these patients with patients with CCC without HL.Among 161 patients with HL from five Italian tertiary hepato-biliary centers, 23 (14.3\%) patients with concomitant CCC were analyzed. The results of surgery in these patients were compared with patients with CCC without HL.The 60.9\% of patients with HL received the diagnosis of CCC intra- or postoperatively, with a resectability rate of 91.3\%. The postoperative morbidity was 61.6\%. The 1- and 3-year survival rates were 78.6\% and 21.0\%, respectively. The recurrence rate was 44.4\% and the 3-year disease-free survival rates were 18.8\%. The comparison with patients with CCC without HL showed a higher resectability rate (p = 0.02) and a higher frequency of earlier stage (p = 0.04) in CCC with HL. Biliary leakage was more frequent in CCC with HL group (p = 0.01) compared to CCC without HL group. We found no differences in overall and disease-free survival between the two groups.Patients with HL and CCC showed a high resectability rate but a higher morbidity. Nevertheless, overall and disease-free survival of patients with CCC and HL showed no differences compared to those of patients with CCC without HL. Also in Western countries, HL needs a careful management for the possible presence of CCC.

Hepatolithiasis-associated cholangiocarcinoma: results from a multi-institutional national database on a case series of 23 patients.

GUGLIELMI, Alfredo;RUZZENENTE, Andrea;VALDEGAMBERI, ALESSANDRO;Bagante, Fabio;CONCI, Simone;IACONO, Calogero
2014

Abstract

Few papers focused on association between hepatolithiasis (HL) and cholangiocarcinoma (CCC) in Western countries. The aims of this paper are to describe the clinical presentation, treatment, and postoperative outcomes of CCC with HL in a cohort of Western patients and to compare the surgical outcomes of these patients with patients with CCC without HL.Among 161 patients with HL from five Italian tertiary hepato-biliary centers, 23 (14.3\%) patients with concomitant CCC were analyzed. The results of surgery in these patients were compared with patients with CCC without HL.The 60.9\% of patients with HL received the diagnosis of CCC intra- or postoperatively, with a resectability rate of 91.3\%. The postoperative morbidity was 61.6\%. The 1- and 3-year survival rates were 78.6\% and 21.0\%, respectively. The recurrence rate was 44.4\% and the 3-year disease-free survival rates were 18.8\%. The comparison with patients with CCC without HL showed a higher resectability rate (p = 0.02) and a higher frequency of earlier stage (p = 0.04) in CCC with HL. Biliary leakage was more frequent in CCC with HL group (p = 0.01) compared to CCC without HL group. We found no differences in overall and disease-free survival between the two groups.Patients with HL and CCC showed a high resectability rate but a higher morbidity. Nevertheless, overall and disease-free survival of patients with CCC and HL showed no differences compared to those of patients with CCC without HL. Also in Western countries, HL needs a careful management for the possible presence of CCC.
Adult, Aged, Aged; 80 and over, Bile Duct Neoplasms; complications/mortality/surgery, Bile Ducts; Intrahepatic, Case-Control Studies, Cholangiocarcinoma; complications/mortality/surgery, Cohort Studies, Databases; Factual, Disease-Free Survival, Female, Hepatectomy, Humans, Lithiasis; complications/surgery, Liver Diseases; complications/surgery, Male, Middle Aged, Neoplasm Recurrence; Local, Prognosis, Treatment Outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/761764
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