Sildenafil and other analogues belonging to the class of the Phosphodiesterase Type 5 inhibitors are widely used in both Europe and the United States as drugs for the treatment of erectile disfunction. However, in the recent years, many herbal remedies and dietary supplements have been marketed claiming Viagra-like activity without the typical side effects of this drug. In some cases these products have been found to contain hidden pharmaceutical active principles, including both approved and unapproved analogues. The present paper reports the structural elucidation of a new sildenafil analogue detected in a dietary supplement marketed with the commercial name of "Quinto Elemento", claiming to be totally natural and free of any warnings about side effects. The identification and characterization of the new molecule was performed through direct infusion ESI-TOF-MS, UV-Spectrophotomety, and by LC-Ion Trap MS analysis
Hidden adulterant boosts the activity of a dietary supplement
GOTTARDO, Rossella;D. Sorio;Trapani, Elisa;
2013-01-01
Abstract
Sildenafil and other analogues belonging to the class of the Phosphodiesterase Type 5 inhibitors are widely used in both Europe and the United States as drugs for the treatment of erectile disfunction. However, in the recent years, many herbal remedies and dietary supplements have been marketed claiming Viagra-like activity without the typical side effects of this drug. In some cases these products have been found to contain hidden pharmaceutical active principles, including both approved and unapproved analogues. The present paper reports the structural elucidation of a new sildenafil analogue detected in a dietary supplement marketed with the commercial name of "Quinto Elemento", claiming to be totally natural and free of any warnings about side effects. The identification and characterization of the new molecule was performed through direct infusion ESI-TOF-MS, UV-Spectrophotomety, and by LC-Ion Trap MS analysis
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