Pulmonary limitations to gas exchange may occur prolonged strenous exercise. For example, increased ventilatory responses have been observed after ultra-endurance disciplines such as a 65-kilometer ultra-marathon or at the end of the running phase in a triathlon race. Over mountain ultra-marathon (MUM) run at a lowe intensity, heart rate and ventilation are lower and cardiac and neuromuscular fatigue are minimal. However, it is unknown if similar phenomenon could be also observed on ventilatory responses. Thus, the aim of this study was to examin the effects of the world's most challenging MUM both on the ventilatory parameters and work of breathing.
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