Alfa-Bisabolol (figure 1), a sesquiterpene alcohol present in essential oils derived from a variety of plants, presents pro-apoptotic activity against several human cancer cell lines. Its poor aqueous solubility limits in vitro and in vivo tests. Herein we report a study of the formulation and characterization of alfa-Bisabolol using poly lactide-co-glycolid acid copolymer nanoparticles (PLGA/B). The human therapeutic treatment of PLGA is approved by US Food and Drug Administration (USFDA) thanks to its biocompatibility. This copolymer is one of the most successfully used in nanomedicine applications since it is hydrolyzed in the body to produce the biodegradable lactic and glycolic acid monomers

Inclusion of α-bisabolol into PLGA nanoparticles enhances its pro-apoptotic activity in human tumoral pancreatic cells.

DARRA, Elena;BOVI, Michele;PERDUCA, Massimiliano;ROMEO, Alessandro;MONACO, Ugo Luigi;MARIOTTO, Sofia Giovanna
2013

Abstract

Alfa-Bisabolol (figure 1), a sesquiterpene alcohol present in essential oils derived from a variety of plants, presents pro-apoptotic activity against several human cancer cell lines. Its poor aqueous solubility limits in vitro and in vivo tests. Herein we report a study of the formulation and characterization of alfa-Bisabolol using poly lactide-co-glycolid acid copolymer nanoparticles (PLGA/B). The human therapeutic treatment of PLGA is approved by US Food and Drug Administration (USFDA) thanks to its biocompatibility. This copolymer is one of the most successfully used in nanomedicine applications since it is hydrolyzed in the body to produce the biodegradable lactic and glycolic acid monomers
PLGA nanoparticles; Alfa-Bisabolol; Pro-apoptotic activity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/640554
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