Silica nanoparticles (SNPs) are a promising carrier system for medical applications. They can be conveniently tailored with different moieties in order to obtain peculiar capabilities. SNPs surface is successfully modified in order to obtain a specific targeting ability through Boletus Edulis Lectin (BEL) bioconjugation, a lectin that specifically recognize overexpressed tumor markers. Moreover, stealthing abilities are imparted with a one-step cocondensation of silanated poly(ethylene) glycol monomethyl ether. Herein we present the preliminary results of these studies.
Stealth silica nanoparticles for theranostic applications
BOVI, Michele;PERDUCA, Massimiliano;
2013
Abstract
Silica nanoparticles (SNPs) are a promising carrier system for medical applications. They can be conveniently tailored with different moieties in order to obtain peculiar capabilities. SNPs surface is successfully modified in order to obtain a specific targeting ability through Boletus Edulis Lectin (BEL) bioconjugation, a lectin that specifically recognize overexpressed tumor markers. Moreover, stealthing abilities are imparted with a one-step cocondensation of silanated poly(ethylene) glycol monomethyl ether. Herein we present the preliminary results of these studies.
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