Third molar displacement into the infratemporal fossa during a surgical extraction is a rare event. Nevertheless, because of the presence of several vascular and neurological trunks through the infratemporal fossa, a correct management of this unusual surgical complication is fundamental in order to avoid many potential serious side effects. In this report, an unusual case of upper third molar displacement into the infratemporal fossa is presented. Detailed radiographic evaluation with CT scans should be performed in order to precisely evaluate the location of the dislocated tooth and the safer surgical corridor to reach it