n-Hexane is a solvent causing peripheral neuropathies. On several occasions it has been postulated that it may act via metabolic products. Therefore, the neurotoxicity of hexanol-1 and hexanol-2, hexane's principal metabolites, was studied. The compounds were given to rats ip for 8 months. Hexanol-1 produced equivocal signs of neurotoxicity in the peripheral nervous system. Hexanol-2 caused a peripheral neuropathy verified both neurophysiologically and histologically. This neuropathy was similar to those observed in experimental polyneuritis due to n-hexane, methyl n-butyl ketone, and 2,5-hexanedione. Hexanol-2 may therefore be considered as a neurotoxic product connecting the metabolic pathways of n-hexane and methyl n-butyl ketone. © 1978.
An experimental study on the neurotoxicity of n-hexane metabolites: hexanol-1 and hexanol-2
PERBELLINI, Luigi;RIZZUTO, Nicolo';SIMONATI, Alessandro
1978-01-01
Abstract
n-Hexane is a solvent causing peripheral neuropathies. On several occasions it has been postulated that it may act via metabolic products. Therefore, the neurotoxicity of hexanol-1 and hexanol-2, hexane's principal metabolites, was studied. The compounds were given to rats ip for 8 months. Hexanol-1 produced equivocal signs of neurotoxicity in the peripheral nervous system. Hexanol-2 caused a peripheral neuropathy verified both neurophysiologically and histologically. This neuropathy was similar to those observed in experimental polyneuritis due to n-hexane, methyl n-butyl ketone, and 2,5-hexanedione. Hexanol-2 may therefore be considered as a neurotoxic product connecting the metabolic pathways of n-hexane and methyl n-butyl ketone. © 1978.
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