Y-chromosomal variability of 17 short tandem repeat (STR) and 18 single nucleotide polymorphisms (SNP) loci was evaluated in three different population samples from Piedmont (North West Italy): Biella (Northern Piedmont, n=80); Trino (Central Piedmont, n=46); Cuneo (Southern Piedmont, n=90). Participating individuals were carefully selected based on their genealogical ancestry: Biella and Cuneo samples included adult males with at least three generations of residence (thus predating the industrial immigration from Southern Italy that took place in the 1950s); the Trino sample consisted of subjects belonging to an association dating back to the Middle-Ages, which limits membership to families who have been settled in the village since the 13th century. AMOVA analysis of Y-SNP haplogroups indicated a variation among individuals within and among sampling areas of 99.97 and 0.03% (p=0.378±0.013), respectively. Trino showed reduced values of Y-STR haplotype diversity (h=0.983), compared to Cuneo (h=0.999) and Biella (h=0.998). Absence of significant variation among sampling areas (0.10%, p=0.350±0.004) was confirmed by AMOVA at haplotype level, andno significant differences were observed when pairwise genetic distances (RST) between the three samples were calculated. On the contrary, multiple significant RST values were obtained when Piedmont samples were compared with available population data from North East, Central and South Italy. The obtained results confirm that, although the Y-chromosomal landscape of Piedmont seems fairly homogeneous, genetic heterogeneity is present in Italy at the inter regional level.

Y chromosome diversity in Piedmont

Caratti, Stefano;
2012

Abstract

Y-chromosomal variability of 17 short tandem repeat (STR) and 18 single nucleotide polymorphisms (SNP) loci was evaluated in three different population samples from Piedmont (North West Italy): Biella (Northern Piedmont, n=80); Trino (Central Piedmont, n=46); Cuneo (Southern Piedmont, n=90). Participating individuals were carefully selected based on their genealogical ancestry: Biella and Cuneo samples included adult males with at least three generations of residence (thus predating the industrial immigration from Southern Italy that took place in the 1950s); the Trino sample consisted of subjects belonging to an association dating back to the Middle-Ages, which limits membership to families who have been settled in the village since the 13th century. AMOVA analysis of Y-SNP haplogroups indicated a variation among individuals within and among sampling areas of 99.97 and 0.03% (p=0.378±0.013), respectively. Trino showed reduced values of Y-STR haplotype diversity (h=0.983), compared to Cuneo (h=0.999) and Biella (h=0.998). Absence of significant variation among sampling areas (0.10%, p=0.350±0.004) was confirmed by AMOVA at haplotype level, andno significant differences were observed when pairwise genetic distances (RST) between the three samples were calculated. On the contrary, multiple significant RST values were obtained when Piedmont samples were compared with available population data from North East, Central and South Italy. The obtained results confirm that, although the Y-chromosomal landscape of Piedmont seems fairly homogeneous, genetic heterogeneity is present in Italy at the inter regional level.
Y-chromosome; STR; piedmont
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/509554
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