Lobular breast carcinoma usually shows poor responsiveness to chemotherapies and often lacks targeted therapies. Since FGFR1 expression has been shown to play pivotal roles in primary breast cancer tumorigenesis, we sought to analyze the status of FGFR1 gene in a metastatic setting of lobular breast carcinoma, since promising FGFR1 inhibitors has been recently developed.
FGFR-1 amplification in metastatic lymph-nodal and haematogenous lobular breast carcinoma.
BRUNELLI, Matteo;Caliò A;MANFRIN, Erminia;NOTTEGAR, Alessia;Bria, Emilio;TORTORA, GIAMPAOLO;PEDRON, Serena;CHILOSI, Marco;ZAMBONI, Giuseppe;MARTIGNONI, Guido;BONETTI, Franco
2012-01-01
Abstract
Lobular breast carcinoma usually shows poor responsiveness to chemotherapies and often lacks targeted therapies. Since FGFR1 expression has been shown to play pivotal roles in primary breast cancer tumorigenesis, we sought to analyze the status of FGFR1 gene in a metastatic setting of lobular breast carcinoma, since promising FGFR1 inhibitors has been recently developed.
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