Background: training is a documented effective treatment in patients affected from peripheral arterial disease. Platelet activation plays a pivotal role in atherosclerosis progression and cardiovascular events. In ischemic heart disease, platelet activation is reduced by aerobic training, while strenuous exercise is associated with enhanced activation. Few data can be found for patients with peripheral arterial disease on training. We aimed to evaluate the effects of aerobic training on platelet activation and oxidative stress at rest and after maximal walking exercise. Methods and Results: we enrolled 27 patients with intermittent claudication. They were submitted to a 15 days aerobic training period (cycling and treadmill exercise under maximal walking capacity). Platelet function (PAF 100 with ADP and epinephrine, P selectin) and oxidative stress (malondyaldehyde) were analyzed at rest and after maximal treadmill test, at the beginning and at the end of the period. At the end of training, absolute walking distance increased (450±180 vs 250±108 m; p<0,05), malondyaldehyde decreased (124±20 vs 147±25 ug/l; p<0,05), P-selectin decreased (0,81±0,31 vs 1,40±0,62 p<0,005), epinephrine platelet activation improved. Maximal treadmill test before training elicited significant ADP platelet activation, while the maximum treadmill test reduced platelets ADP activation at the end of training; the test caused increase in malondyaldeyde concentration at the beginning and at the end of protocol . Conclusions: training can cause an improvement of endothelial function and an increased release of NO and prostacyclin, these substances exert favorable effects on platelets function. Furthermore ischemia-reperfusion, elicited by maximal treadmill test, increases the release of ADP that is inversely reduced after training. Aerobic supervised training in patients with peripheral arterial disease improves platelets aggregation, oxidative stress and platelets aggregation during maximal exercise. These data help explaining the benefit of training in PAD and atherosclerosis.

Platelets activation with claudicatio intermittens: effects of physical training on at rest and after induction of ischemia.

DE MARCHI, Sergio;ZECCHETTO, Sara;PRIOR, MANLIO;RIGONI, Annamaria;GELATI, Matteo;AROSIO, Enrico
2012

Abstract

Background: training is a documented effective treatment in patients affected from peripheral arterial disease. Platelet activation plays a pivotal role in atherosclerosis progression and cardiovascular events. In ischemic heart disease, platelet activation is reduced by aerobic training, while strenuous exercise is associated with enhanced activation. Few data can be found for patients with peripheral arterial disease on training. We aimed to evaluate the effects of aerobic training on platelet activation and oxidative stress at rest and after maximal walking exercise. Methods and Results: we enrolled 27 patients with intermittent claudication. They were submitted to a 15 days aerobic training period (cycling and treadmill exercise under maximal walking capacity). Platelet function (PAF 100 with ADP and epinephrine, P selectin) and oxidative stress (malondyaldehyde) were analyzed at rest and after maximal treadmill test, at the beginning and at the end of the period. At the end of training, absolute walking distance increased (450±180 vs 250±108 m; p<0,05), malondyaldehyde decreased (124±20 vs 147±25 ug/l; p<0,05), P-selectin decreased (0,81±0,31 vs 1,40±0,62 p<0,005), epinephrine platelet activation improved. Maximal treadmill test before training elicited significant ADP platelet activation, while the maximum treadmill test reduced platelets ADP activation at the end of training; the test caused increase in malondyaldeyde concentration at the beginning and at the end of protocol . Conclusions: training can cause an improvement of endothelial function and an increased release of NO and prostacyclin, these substances exert favorable effects on platelets function. Furthermore ischemia-reperfusion, elicited by maximal treadmill test, increases the release of ADP that is inversely reduced after training. Aerobic supervised training in patients with peripheral arterial disease improves platelets aggregation, oxidative stress and platelets aggregation during maximal exercise. These data help explaining the benefit of training in PAD and atherosclerosis.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/484752
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