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EnglishContamination, degradation or unsuitable storage conditions of biological samples may produce partial genetic profiles and amplification artifacts of difficult interpretation. Allele drop-out is one of the most frequent stochastic artifacts involving degraded DNA. We report a case where a woman tested positive for alcohol tests performed on blood samples taken following the police custody, had doubts about the origin of the biological sample (blood) analyzed. After a few weeks she has required the comparison of its genetic profile obtained from a saliva sample with that obtained from the blood sample that had been preserved. A stain of blood sample was placed on paper and was divided into four parts, one of these was immediately analyzed, providing a genetic profile that was not compatible with the genetic profile of the woman. Subsequently, another part of the bloodstain was underwent to genetic analysis providing a different genetic profile than the previous stain, but fully compatible with that of the woman. Unexpectedly, two portions of the same trace have produced two different profiles.
| Titolo: | Two different genetic profiles from a bloodstain: which one is true? | |
| Autori: | ||
| Data di pubblicazione: | 2012 | |
| Rivista: | ||
| Abstract: | Contamination, degradation or unsuitable storage conditions of biological samples may produce partial genetic profiles and amplification artifacts of difficult interpretation. Allele drop-out is one of the most frequent stochastic artifacts involving degraded DNA. We report a case where a woman tested positive for alcohol tests performed on blood samples taken following the police custody, had doubts about the origin of the biological sample (blood) analyzed. After a few weeks she has required the comparison of its genetic profile obtained from a saliva sample with that obtained from the blood sample that had been preserved. A stain of blood sample was placed on paper and was divided into four parts, one of these was immediately analyzed, providing a genetic profile that was not compatible with the genetic profile of the woman. Subsequently, another part of the bloodstain was underwent to genetic analysis providing a different genetic profile than the previous stain, but fully compatible with that of the woman. Unexpectedly, two portions of the same trace have produced two different profiles. | |
| Handle: | http://hdl.handle.net/11562/454541 | |
| Appare nelle tipologie: | 04.01 Contributo in atti di convegno |
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