Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a trans-intestinal elimination. The inhibitory effects of Itz on the pharmaco-metabolizing system should be considered in the kinetics of Cpx. Objective of the research was to study the effect of Itz on the intestinal kinetics of Cpx following different administration schedule in rat.

Behaviour of ciprofloxacin intestinal pharmacokinetics after different timing of Itraconazole administration

BERTAZZONI MINELLI, Elisa;BENINI, Anna
2011

Abstract

Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a trans-intestinal elimination. The inhibitory effects of Itz on the pharmaco-metabolizing system should be considered in the kinetics of Cpx. Objective of the research was to study the effect of Itz on the intestinal kinetics of Cpx following different administration schedule in rat.
itraconazole; trans-intestinal elimination; ciprofloxacin
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/417542
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