Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a trans-intestinal elimination. The inhibitory effects of Itz on the pharmaco-metabolizing system should be considered in the kinetics of Cpx. Objective of the research was to study the effect of Itz on the intestinal kinetics of Cpx following different administration schedule in rat.
Behaviour of ciprofloxacin intestinal pharmacokinetics after different timing of Itraconazole administration
BERTAZZONI MINELLI, Elisa;BENINI, Anna
2011-01-01
Abstract
Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a trans-intestinal elimination. The inhibitory effects of Itz on the pharmaco-metabolizing system should be considered in the kinetics of Cpx. Objective of the research was to study the effect of Itz on the intestinal kinetics of Cpx following different administration schedule in rat.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
