The resistance to aminoglycosides is increasing and the combination with vancomycin (V) is useful in orthopaedic infections. Gentamicin (G) and V are known to have a potential nephrotoxic effect, especially when administered in combination for systemic use. Toxic serum levels are > 10 mg/l for G and > 60 mg/l for V, respectively. Industrial spacers loaded with Gentamicin and Vancomycin (Vancogenx-Space, Tecres, Verona) were studied in a multicenter clinical trial. The primary objective was to assess their safety when implanted in patients with prosthetic joint infection (two-stage revision), mainly when the spacer devices are utilized along with the antimicrobial systemic therapy. Fourteen centres specialized in Orthopaedics and Traumatology were involved in the study. Serum and urine concentrations of G and V were determined by FPIA method at different time (24, 48, 72, and 120 hours) after spacer implant. Renal function parameters (renal clearance, serum creatinine, and BUN) have been evaluated during the trial.

Vancogenx-space for hip and knee: gentamicin and vancomycin levels in serum and urine from a multicenter trial

BERTAZZONI MINELLI, Elisa;BENINI, Anna
2011

Abstract

The resistance to aminoglycosides is increasing and the combination with vancomycin (V) is useful in orthopaedic infections. Gentamicin (G) and V are known to have a potential nephrotoxic effect, especially when administered in combination for systemic use. Toxic serum levels are > 10 mg/l for G and > 60 mg/l for V, respectively. Industrial spacers loaded with Gentamicin and Vancomycin (Vancogenx-Space, Tecres, Verona) were studied in a multicenter clinical trial. The primary objective was to assess their safety when implanted in patients with prosthetic joint infection (two-stage revision), mainly when the spacer devices are utilized along with the antimicrobial systemic therapy. Fourteen centres specialized in Orthopaedics and Traumatology were involved in the study. Serum and urine concentrations of G and V were determined by FPIA method at different time (24, 48, 72, and 120 hours) after spacer implant. Renal function parameters (renal clearance, serum creatinine, and BUN) have been evaluated during the trial.
Vancogenx-space, gentamicin-vancomycin combination, nephrotoxic effect, multicenter clinical trial
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/417540
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact