Polymethylmethacrylate (PMMA) bone cement, commonly used for the fixation of joint prostheses and also for orthopaedic devices, may be colonised by Gram positive cocci. The use of antibiotic-loaded PMMA should prevent bacterial colonisation of cement surfaces. Biofilm formation on bone cement could be more effectively reduced by incorporation of a second antibiotic The aim of our study was to evaluate the in vitro effects of gentamicin (G)- and vancomycin (V)-loaded PMMA cement specimens on the bacterial adhesion of multi-resistant clinical isolates staphylococci.
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