Polymethylmetacrylate bone cement (PMMA), used to prepare joint prostheses and also for their fixation, is commonly used as a carrier to release antibiotics into the site of infection. The purpose of this research is to determine the antibiotic concentration in infection site of rabbits with experimental acute osteomyelitis induced by Methicillin-Resistant S. aureus (MRSA) and treated with 1- PMMA bone cements (intramedullary nails) loaded with gentamicin (G) and vancomycin (V) in combination and 2- systemic teicoplanin (T) administration. This research is part of the study made in collaboration with the Rizzoli Orthopaedic Institute, the results of which were presented separately. We studied the distribution of these two antibiotics in different bone fractions of the femur and determined the serum levels collected at removal of the intramedullary nails.
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