Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a transintestinal elimination. An effect of Itz on Cpx pharmacokinetics is possible. Objective of this research is to study the in vivo drug interactions between Cpx and Itz at gastrointestinal level in rat. We studied the distribution of Cpx in gastrointestinal tract and the expression of pharmaco-metabolizing system CYP450 and Pgp (intestine and liver).

Effects of itraconazole on the pharmacokinetics of ciprofloxacin and the intestinal metabolizing system (CYP450 and P-glycoprotein)

BENINI, Anna;BERTAZZONI MINELLI, Elisa
2011

Abstract

Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a transintestinal elimination. An effect of Itz on Cpx pharmacokinetics is possible. Objective of this research is to study the in vivo drug interactions between Cpx and Itz at gastrointestinal level in rat. We studied the distribution of Cpx in gastrointestinal tract and the expression of pharmaco-metabolizing system CYP450 and Pgp (intestine and liver).
drug interaction, ciprofloxacin, itraconazole, CYP450, P-glycoprotein
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/417141
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact