Itraconazole (Itz), an antifungal azole and a strong inhibitor of the liver metabolism, can modify the pharmacokinetic parameters of various drugs. Ciprofloxacin (Cpx), a fluoroquinolone widely utilized in clinical practice, exhibits a transintestinal elimination. An effect of Itz on Cpx pharmacokinetics is possible. Objective of this research is to study the in vivo drug interactions between Cpx and Itz at gastrointestinal level in rat. We studied the distribution of Cpx in gastrointestinal tract and the expression of pharmaco-metabolizing system CYP450 and Pgp (intestine and liver).
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