Different microbial biofilm formation on polymethylmathacrylate (PMMA) bone cement loaded with gentamicin and vancomycin

Adhesion of pathogenic bacteria to the surface of Polymethylmethacrylate (PMMA) bone cement is considered to be the critical event in the development of infection during total hip arthroplasty.PMMA bone cement is commonly used for the fixation of joint prostheses and also for the production of orthopaedic devices (beads, spacers, etc.) PMMA may be colonised by gram positive cocci, but the use of antibiotic-loaded PMMA cement (gentamicin, vancomycin) should prevent bacterial colonization of cement surfaces and/or reduce the capacity of adhesion of bacteria compared to plain PMMA