Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.

The role of mitochondria in neurodegenerative diseases.

FILOSTO, Massimiliano;SCARPELLI, Mauro;TONIN, PAOLA;TOMELLERI, Giuliano;
2011-01-01

Abstract

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.
2011
Alzheimer’s disease; Amyotrophic lateral sclerosis; Huntington disease; Inclusion body myopathy; Mitochondria; mtDNA; Neurodegenerative disorders; Parkinson’s disease
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/353445
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