Standard resections for benign and borderline neoplasms of the pancreas are associated with a significant risk of long-term functional impairment, whereas enucleation preserves healthy parenchyma and pancreatic function. The aim of this study was to evaluate postoperative and long-term oncological and functional results after pancreatic enucleation.Data collected prospectively from 61 consecutive patients who underwent pancreatic enucleation were analysed.There were no deaths. A clinically significant pancreatic fistula was reported in 14 patients (23 per cent), and five patients (8 per cent) had a further operation for fistula-related complications. The most common indication for surgery was endocrine neoplasm (38 patients; 62 per cent) and two patients (3 per cent) had a final histopathological diagnosis of malignant neoplasm. At a median follow-up of 61 months no patient had developed tumour recurrence or exocrine insufficiency. Two elderly patients developed non-insulin-dependent diabetes.Enucleation is an effective procedure for the radical treatment of benign and borderline neoplasms of the pancreas, with good long-term outcomes.

Enucleation of pancreatic neoplasms.

CRIPPA, Stefano;BASSI, Claudio;SALVIA, Roberto;FALCONI, Massimo;BUTTURINI, Giovanni;PEDERZOLI, Paolo
2007-01-01

Abstract

Standard resections for benign and borderline neoplasms of the pancreas are associated with a significant risk of long-term functional impairment, whereas enucleation preserves healthy parenchyma and pancreatic function. The aim of this study was to evaluate postoperative and long-term oncological and functional results after pancreatic enucleation.Data collected prospectively from 61 consecutive patients who underwent pancreatic enucleation were analysed.There were no deaths. A clinically significant pancreatic fistula was reported in 14 patients (23 per cent), and five patients (8 per cent) had a further operation for fistula-related complications. The most common indication for surgery was endocrine neoplasm (38 patients; 62 per cent) and two patients (3 per cent) had a final histopathological diagnosis of malignant neoplasm. At a median follow-up of 61 months no patient had developed tumour recurrence or exocrine insufficiency. Two elderly patients developed non-insulin-dependent diabetes.Enucleation is an effective procedure for the radical treatment of benign and borderline neoplasms of the pancreas, with good long-term outcomes.
Adolescent; Adult; Aged; 80 and over; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pancreatic Fistula; Pancreatic Neoplasms; Postoperative Complications; Preoperative Care; Prospective Studies
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/353412
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