Purpose: To compare contrast-enhanced computed tomography (CECT), contrast-enhanced magnetic resonance imaging (MRI) and contrast-enhanced ultra-sonography (CEUS) enhancement patterns of functioning (FPET) and non-functioning pancreatic endocrine tumours (NPET) Methods and Materials: In a 6-year-period, 125 consecutive patients preoperatively studied with at least two contrast enhanced exams (98 NPETs, 27 FPETs) were included in our retrospective study. A total of 94 CT, 83 MRI, 69 CEUS studies were performed; all CT and MRI exams were performed before and after i.v. administration of contrast material, including arterial pancreatic (45 sec), portal venous (80 sec) and late venous phase (120 sec); CEUS was performed with continuous observation of lesion enhancement from unenhanced (B-mode) to late venous phase. Student's t test was used to compare enhancement patterns (hyper-iso-hypovascularity in comparison with spared pancreas, homo-inhomogenous enhancement, peak enhancement phase). A value of p < 0.05 was considered significant. Results: Lesion hypervascularity was depicted in 76/94 (80.8%) CT, 70/83 (84.3%) MRI and 54/69 (78.2%) CEUS exams, without significant difference between NPET and FPET (p > 0.05). A non-significant difference was determined as cocers enhancement patterns (hypervascularity and homogeneity) between CT and MRI (p = 0.1), CT and CEUS (p = 0.1), MRI and CEUS (p > 0.05). Conversely, there was a significant difference regarding the peak enhancement phase between CT and MRI with respect to CEUS (p = 0.03). Conclusions: In case of doubtful findings, an additional enhanced study may be useful to confirm hypervascularity, representing the key for characterising NPET and for identifying FPET.
Endocrine tumours of the pancreas: discordant patterns of enhancement at contrast-enhanced CT, contrast- enhanced MRI and CEUS
FACCIOLI, Niccolò;MANFREDI, Riccardo;POZZI MUCELLI, Roberto
2011-01-01
Abstract
Purpose: To compare contrast-enhanced computed tomography (CECT), contrast-enhanced magnetic resonance imaging (MRI) and contrast-enhanced ultra-sonography (CEUS) enhancement patterns of functioning (FPET) and non-functioning pancreatic endocrine tumours (NPET) Methods and Materials: In a 6-year-period, 125 consecutive patients preoperatively studied with at least two contrast enhanced exams (98 NPETs, 27 FPETs) were included in our retrospective study. A total of 94 CT, 83 MRI, 69 CEUS studies were performed; all CT and MRI exams were performed before and after i.v. administration of contrast material, including arterial pancreatic (45 sec), portal venous (80 sec) and late venous phase (120 sec); CEUS was performed with continuous observation of lesion enhancement from unenhanced (B-mode) to late venous phase. Student's t test was used to compare enhancement patterns (hyper-iso-hypovascularity in comparison with spared pancreas, homo-inhomogenous enhancement, peak enhancement phase). A value of p < 0.05 was considered significant. Results: Lesion hypervascularity was depicted in 76/94 (80.8%) CT, 70/83 (84.3%) MRI and 54/69 (78.2%) CEUS exams, without significant difference between NPET and FPET (p > 0.05). A non-significant difference was determined as cocers enhancement patterns (hypervascularity and homogeneity) between CT and MRI (p = 0.1), CT and CEUS (p = 0.1), MRI and CEUS (p > 0.05). Conversely, there was a significant difference regarding the peak enhancement phase between CT and MRI with respect to CEUS (p = 0.03). Conclusions: In case of doubtful findings, an additional enhanced study may be useful to confirm hypervascularity, representing the key for characterising NPET and for identifying FPET.
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