Purpose: To evaluate location and pathological outcome of breast MRI suspicious lesions in patients with newly diagnosed ipsilateral/controlateral breast cancer. Methods and Materials: Among 310 consecutive pre-operative breast MRI, 71 lesions (evident on MR images, non-palpable, first-look ultrasound and mammographically occult) were recommended for second-look ultrasound. The retrospective evaluation included second-look ultrasound identification according to lesion's location (ipsilateral - in the same/different quadrant - controlateral), distance from the primary lesions (<4 cm/>4 cm). Results were correlated with pathological findings. Results: Of 50 lesions depicted at second-look ultrasound, 26 lesions were ipsilateral to the known cancer and 24 were controlateral. Overall, 16/26 (61%) ipsilateral lesions were malignant. Of the 26 ipsilateral lesions, 12 (24%) were in the same quadrant as the index cancer, of which 8 (66%) were malignant (4-ILC, 3-IDC, 1-DCIS) and 4 were benign. The remaining 14/26 (28%) ipsilateral lesions were in different quadrant from the known cancer; 8 (57%) were malignant (5-ILC, 3-DCIS) and 6 were benign. Of the 24 controlateral lesions to known cancer, 4/24(16%) were malignant (2-ILC, 2-IDC). Overall, of the 20/50 (40%) malignant lesions identified by second-look ultrasound, 13/20 (65%) were within 4 cm distance from the primary (p < 0.05). Conclusions: Second look ultrasound identified 71 % of incidental breast MRI lesions in newly diagnosed breast cancer patients, of which 40 % proved malignant. The majority (65%) of additional tumour foci are in the same quadrant and within 4 cm of the index cancer. At a minimum, when performing ultrasound in a patient known to have cancer, thorough evaluation of at least that quadrant of the breast is recommended.

Second-look ultrasound of incidental breast MRI lesions in patients with newly diagnosed breast cancer: correlating location with pathology

CARBOGNIN, Giovanni;BONETTI, Franco;POZZI MUCELLI, Roberto
2011-01-01

Abstract

Purpose: To evaluate location and pathological outcome of breast MRI suspicious lesions in patients with newly diagnosed ipsilateral/controlateral breast cancer. Methods and Materials: Among 310 consecutive pre-operative breast MRI, 71 lesions (evident on MR images, non-palpable, first-look ultrasound and mammographically occult) were recommended for second-look ultrasound. The retrospective evaluation included second-look ultrasound identification according to lesion's location (ipsilateral - in the same/different quadrant - controlateral), distance from the primary lesions (<4 cm/>4 cm). Results were correlated with pathological findings. Results: Of 50 lesions depicted at second-look ultrasound, 26 lesions were ipsilateral to the known cancer and 24 were controlateral. Overall, 16/26 (61%) ipsilateral lesions were malignant. Of the 26 ipsilateral lesions, 12 (24%) were in the same quadrant as the index cancer, of which 8 (66%) were malignant (4-ILC, 3-IDC, 1-DCIS) and 4 were benign. The remaining 14/26 (28%) ipsilateral lesions were in different quadrant from the known cancer; 8 (57%) were malignant (5-ILC, 3-DCIS) and 6 were benign. Of the 24 controlateral lesions to known cancer, 4/24(16%) were malignant (2-ILC, 2-IDC). Overall, of the 20/50 (40%) malignant lesions identified by second-look ultrasound, 13/20 (65%) were within 4 cm distance from the primary (p < 0.05). Conclusions: Second look ultrasound identified 71 % of incidental breast MRI lesions in newly diagnosed breast cancer patients, of which 40 % proved malignant. The majority (65%) of additional tumour foci are in the same quadrant and within 4 cm of the index cancer. At a minimum, when performing ultrasound in a patient known to have cancer, thorough evaluation of at least that quadrant of the breast is recommended.
2011
breast MRI; US; cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/349437
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