Tumors are complex bio-systems and cell growth is coupled to the chemical modifications of the extracellular microenvironment. Tumor cells and their microenvironment, therefore, constitute an evolving cellular ecosystem and a detailed understanding of the underlying dynamics might provide insights into tumor development and resistance to therapy. Here we present a real-life computer program for the simulation of multicell tumor spheroids. Simulation results compare quite well with experimental data and yields unique view of tumor microenvironment.
Tumor microenvironment in a real-life model of tumor spheroids
CHIGNOLA, Roberto;
2010-01-01
Abstract
Tumors are complex bio-systems and cell growth is coupled to the chemical modifications of the extracellular microenvironment. Tumor cells and their microenvironment, therefore, constitute an evolving cellular ecosystem and a detailed understanding of the underlying dynamics might provide insights into tumor development and resistance to therapy. Here we present a real-life computer program for the simulation of multicell tumor spheroids. Simulation results compare quite well with experimental data and yields unique view of tumor microenvironment.
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