Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimposable pharmacokinetics in both serum and pancreatic juice.

Piperacillin-Tazobactam penetration in pacreatic juice

BERTAZZONI MINELLI, Elisa;BENINI, Anna;FRANCO, Luigina;BASSI, Claudio;PEDERZOLI, Paolo
2008-01-01

Abstract

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimposable pharmacokinetics in both serum and pancreatic juice.
2008
COMPLICATED INTRAABDOMINAL INFECTION, CONTINUOUS-INFUSION, NECROTIZING PANCREATITIS,
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/322707
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