Background: Increased oxidative stress is thought to play a role in the pathogenesis of the atherothrombotic process. Paraoxonases (PONs) are closely related antioxidant enzymes encoded by clustered genes on chromosome 7q. We evaluated three PON polymorphisms (PON1 Leu55Met and Gln 192Arg; PON2 Ser311Cys) as possible risk factors for coronary atherosclerotic disease (CAD) and/or its main thrombotic complication, myocardial infarction (MI). Materials and methods: We studied 890 subjects with angiographic documentation of coronary vessels (272 = CAD-free; 618 = CAD). In the CAD group, 341 subjects had a previous MI. Results: Frequencies of various genotypes were not significantly different between CAD-free subjects and the entire CAD population. In the latter group, there were more carriers of the PON2 311Cys variation among those who had suffered a MI than among those who had not (P < 0.01 by χ2). The adjusted OR for MI among PON2 311Cys carriers was 1.5 (95 % CI, 1.03-2.19). A gene-env...
Interaction between smoking and PON2 Ser311 Cys polymorphism as a determinant of the risk of myocardial infarction
MARTINELLI, Nicola;GIRELLI, Domenico;OLIVIERI, Oliviero;TRABETTI, Elisabetta;PIZZOLO, Francesca;FRISO, Simonetta;TENUTI, Ilaria;PIGNATTI, Pierfranco;CORROCHER, Roberto
2004-01-01
Abstract
Background: Increased oxidative stress is thought to play a role in the pathogenesis of the atherothrombotic process. Paraoxonases (PONs) are closely related antioxidant enzymes encoded by clustered genes on chromosome 7q. We evaluated three PON polymorphisms (PON1 Leu55Met and Gln 192Arg; PON2 Ser311Cys) as possible risk factors for coronary atherosclerotic disease (CAD) and/or its main thrombotic complication, myocardial infarction (MI). Materials and methods: We studied 890 subjects with angiographic documentation of coronary vessels (272 = CAD-free; 618 = CAD). In the CAD group, 341 subjects had a previous MI. Results: Frequencies of various genotypes were not significantly different between CAD-free subjects and the entire CAD population. In the latter group, there were more carriers of the PON2 311Cys variation among those who had suffered a MI than among those who had not (P < 0.01 by χ2). The adjusted OR for MI among PON2 311Cys carriers was 1.5 (95 % CI, 1.03-2.19). A gene-env...
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