The results of preliminary researc are: according to dose i) fluoroquinolones can interact with cellular DNA and interfere with metabolic system; ii) fluoroquinolones' effects are structure-specific and selective on the intestinal environment. In conclusion, fluoroquinolones showed diferences in the intestinal kinetics and toxicological features within the class
FLUOROQUINOLONES: EFFECTS OF DOSE ON INTESTINAL PENETRATION, HEPATIC ISOFORM AND DNA DAMAGE IN RAT.
BERTAZZONI MINELLI, Elisa;BENINI, Anna;DORIA, Denise;FRANCESCHETTI, Paola;FRACASSO, Maria Enrica
2005-01-01
Abstract
The results of preliminary researc are: according to dose i) fluoroquinolones can interact with cellular DNA and interfere with metabolic system; ii) fluoroquinolones' effects are structure-specific and selective on the intestinal environment. In conclusion, fluoroquinolones showed diferences in the intestinal kinetics and toxicological features within the class
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