Faeces can inhibit the antimiocrobial activity of some antibiotics in the gut. We evaluate antimicrobial activity of cefetamet pivoxil and ramoplanin in presence of faeces and factor affecting their activity in intestinal content. The antimicrobil activity of ceftamet pivoxil was reduced to 60% by sterile faeces and more evident in presence of faeces. Ramoplanin seems not to be inactivated by intestinal bacterial flora. Ramoplanin offers a great potential for oral use in selective gut decontamination. Cefetamet pivoxil shoul be considered an ecological antibiotic sparing the inteatinal microflora.
Antibiotics and intestinal contents interaction
BERTAZZONI MINELLI, Elisa;BENINI, Anna;
1994-01-01
Abstract
Faeces can inhibit the antimiocrobial activity of some antibiotics in the gut. We evaluate antimicrobial activity of cefetamet pivoxil and ramoplanin in presence of faeces and factor affecting their activity in intestinal content. The antimicrobil activity of ceftamet pivoxil was reduced to 60% by sterile faeces and more evident in presence of faeces. Ramoplanin seems not to be inactivated by intestinal bacterial flora. Ramoplanin offers a great potential for oral use in selective gut decontamination. Cefetamet pivoxil shoul be considered an ecological antibiotic sparing the inteatinal microflora.
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