Immunotherapy with monoclonal antibody (mAb)-vehicled toxins may be a novel treatment option for the management of androgen-independent Prostate Cancer. To investigate the therapeutic potential of anti-prostate specific membrane antigen (PSMA) mAb-ricin A-chain Immunotoxins (ITS) in monolayer and 3D cell cultures of prostate carcinoma cell lines (LNCaP), (J591, PEQ226.5, PM2PO79.1).
Anti PSMA immunotoxins activity against prostate cancer cell lines.
FRACASSO, Giulio;CINGARLINI, Sara;BELLISOLA, GIUSEPPE;RIGHETTI, Sabrina;CHIESA, ELENA;COLOMBATTI, Marco
2002-01-01
Abstract
Immunotherapy with monoclonal antibody (mAb)-vehicled toxins may be a novel treatment option for the management of androgen-independent Prostate Cancer. To investigate the therapeutic potential of anti-prostate specific membrane antigen (PSMA) mAb-ricin A-chain Immunotoxins (ITS) in monolayer and 3D cell cultures of prostate carcinoma cell lines (LNCaP), (J591, PEQ226.5, PM2PO79.1).
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