Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with histologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p less than 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.

Reduction of liver glutathione peroxidase activity and deficiency of serum selenium in patients with hepatocellular carcinoma

CORROCHER, Roberto;BELLISOLA, GIUSEPPE;
1986-01-01

Abstract

Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with histologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p less than 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.
1986
hepatocellular carcinoma (HCC); serum selenium concentration; glutathione peroxidase (GSH-Px)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1927
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