Hyperthermia, a limited increase in tumor tissue temperature up to a maximum of 45° C, is considered a promising therapeutic approach thanks to the capability of localized treatment with negligible systemic toxicity. Among different hyperthermia methods, photothermal therapy (PTT) and magnetic fluid hyperthermia (MFH) have attracted extensive research attention in the last decades. In this work, we investigated innovative Iron-Boron (Fe-B) nanoparticles (NPs) as PTT and MFH agents. Such NPs can convert near-infrared light(NIR) and magnetic energy into heat. Here we report preliminary results of Fe-B NPs as multimodal therapeutic agents and as diagnostic agents in MRI. Potential use of Iron-Boron (FeB) NPs as photothermal therapy agents, combining their photothermal and magnetic properties and exploiting the possibility to use them as MRI contrast agent.
Iron-Boron nanoparticles as diagnostic agent in MRI and therapeutic agent in Photothermal and Magnetic Fluid Hyperthermia.
Alessandro Negri;Arnaud Martino Capuzzo;Pasquina Marzola
2023-01-01
Abstract
Hyperthermia, a limited increase in tumor tissue temperature up to a maximum of 45° C, is considered a promising therapeutic approach thanks to the capability of localized treatment with negligible systemic toxicity. Among different hyperthermia methods, photothermal therapy (PTT) and magnetic fluid hyperthermia (MFH) have attracted extensive research attention in the last decades. In this work, we investigated innovative Iron-Boron (Fe-B) nanoparticles (NPs) as PTT and MFH agents. Such NPs can convert near-infrared light(NIR) and magnetic energy into heat. Here we report preliminary results of Fe-B NPs as multimodal therapeutic agents and as diagnostic agents in MRI. Potential use of Iron-Boron (FeB) NPs as photothermal therapy agents, combining their photothermal and magnetic properties and exploiting the possibility to use them as MRI contrast agent.
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