The use of adult adipose-derived stem cells (ADAS) as a treatment for neurological diseases is in promising development. Extracellular vesicles such as exosomes (EXO), which impact surrounding cells, are the main biological agents of ADAS. Exosome localization and tracking techniques need to be effective and non-invasive in the current development of exosome therapies. Exosomes must be labeled with contrast agents, such as ferrous superparamagnetic nanoparticles (NPs). The current research project aims to validate the therapeutic efficacy of ADAS-derived EXOs labelled with different NPs in models of neurodegenerative diseases, capable of providing an imaging and cell therapy approach.

From isolation of adult adipose tissue derived stem cells ADAS to labelling with superparamagnetic iron oxide nanoparticles: first approaches to unleash the potential

Arnaud Martino Capuzzo
Writing – Original Draft Preparation
;
Ilaria Scambi
Supervision
;
Raffaella Mariotti
Project Administration
;
Pasquina Marzola
Project Administration
2023-01-01

Abstract

The use of adult adipose-derived stem cells (ADAS) as a treatment for neurological diseases is in promising development. Extracellular vesicles such as exosomes (EXO), which impact surrounding cells, are the main biological agents of ADAS. Exosome localization and tracking techniques need to be effective and non-invasive in the current development of exosome therapies. Exosomes must be labeled with contrast agents, such as ferrous superparamagnetic nanoparticles (NPs). The current research project aims to validate the therapeutic efficacy of ADAS-derived EXOs labelled with different NPs in models of neurodegenerative diseases, capable of providing an imaging and cell therapy approach.
2023
Extracellular vesicles, Nanoparticles, Stem cells, Exosomes
File in questo prodotto:
File Dimensione Formato  
FROMIS~1.PDF

accesso aperto

Tipologia: Documento in Post-print
Licenza: Dominio pubblico
Dimensione 311.83 kB
Formato Adobe PDF
311.83 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1088368
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact