From isolation of adult adipose tissue derived stem cells ADAS to labelling with superparamagnetic iron oxide nanoparticles: first approaches to unleash the potential

The use of adult adipose-derived stem cells (ADAS) as a treatment for neurological diseases is in promising development. Extracellular vesicles such as exosomes (EXO), which impact surrounding cells, are the main biological agents of ADAS. Exosome localization and tracking techniques need to be effective and non-invasive in the current development of exosome therapies. Exosomes must be labeled with contrast agents, such as ferrous superparamagnetic nanoparticles (NPs). The current research project aims to validate the therapeutic efficacy of ADAS-derived EXOs labelled with different NPs in models of neurodegenerative diseases, capable of providing an imaging and cell therapy approach.