: Advanced glycation end products (AGEs) are biologically active compounds formed physiologically throughout a sequence of chemical reactions, to generate highly oxidant‐reactive aldehydes that combine covalently to proteins. They accumulate slowly in tissues during ageing but also in metabolic and selected inflammatory disorders. Accumulation of AGEs occurs more rapidly and intensely in the skin and serum of patients with type 2 diabetes, obesity, cardiovascular dis‐ eases, chronic renal insufficiency, and non‐alcoholic fatty liver disease and also in the skin of pa‐ tients with psoriasis. All of the above conditions are intimately associated with psoriasis. Interaction of AGEs with their receptors (RAGEs) stimulates cellular signaling with the formation of reactive oxygen species and activation of nuclear factor kappa light chain enhancer of activated B (NF‐kB), which is a key regulator in the expression of inflammatory mediators and the production of oxida‐ tive stress. Thus, AGEs may play an interesting pathogenic role in the intersection of inflammatory and metabolic diseases, may represent a biomarker of inflammation and a potential target for novel therapeutic strategies. This is a narrative review with the objective to summarize current evidence on the role of AGEs in psoriasis

Advanced Glycation End Products and Psoriasis

Martina Maurelli;Paolo Gisondi;Giampiero Girolomoni
2023-01-01

Abstract

: Advanced glycation end products (AGEs) are biologically active compounds formed physiologically throughout a sequence of chemical reactions, to generate highly oxidant‐reactive aldehydes that combine covalently to proteins. They accumulate slowly in tissues during ageing but also in metabolic and selected inflammatory disorders. Accumulation of AGEs occurs more rapidly and intensely in the skin and serum of patients with type 2 diabetes, obesity, cardiovascular dis‐ eases, chronic renal insufficiency, and non‐alcoholic fatty liver disease and also in the skin of pa‐ tients with psoriasis. All of the above conditions are intimately associated with psoriasis. Interaction of AGEs with their receptors (RAGEs) stimulates cellular signaling with the formation of reactive oxygen species and activation of nuclear factor kappa light chain enhancer of activated B (NF‐kB), which is a key regulator in the expression of inflammatory mediators and the production of oxida‐ tive stress. Thus, AGEs may play an interesting pathogenic role in the intersection of inflammatory and metabolic diseases, may represent a biomarker of inflammation and a potential target for novel therapeutic strategies. This is a narrative review with the objective to summarize current evidence on the role of AGEs in psoriasis
2023
psoriasis; advanced glycation end products; AGEs; inflammation; autoimmunity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1087470
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