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EnglishThe rationale behind this work lies in an optimization of the nanoformulation DOXO- BMNPs, already demonstrated to be more efficient against tumor cells, both in vitro and in vivo, than systemic traditional therapies. By embedding DOXO-BMNPs into PLGA, which is further functionalized with the cell- penetrating TAT peptide, the resulting nanoassembly is able to mediate drug transport (using DOXO as a drug model) and behaves as a hyperthermic agent (induced by an alternating magnetic field (AMF) or by laser irradiation with a laser power density of 2 W/cm2).
| Titolo: | Enhanced Cytotoxic Effect of TAT–PLGA-Embedded DOXO Carried by Biomimetic Magnetic Nanoparticles upon Combination with Magnetic Hyperthermia and Photothermia | |
| Autori: | ||
| Data di pubblicazione: | 2021 | |
| Abstract: | The rationale behind this work lies in an optimization of the nanoformulation DOXO- BMNPs, already demonstrated to be more efficient against tumor cells, both in vitro and in vivo, than systemic traditional therapies. By embedding DOXO-BMNPs into PLGA, which is further functionalized with the cell- penetrating TAT peptide, the resulting nanoassembly is able to mediate drug transport (using DOXO as a drug model) and behaves as a hyperthermic agent (induced by an alternating magnetic field (AMF) or by laser irradiation with a laser power density of 2 W/cm2). | |
| Handle: | http://hdl.handle.net/11562/1049933 | |
| Appare nelle tipologie: | 04.03 Poster |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2021_PROGRAMMA_web_23_settembre 2_compressed.pdf | Book of Abstract | Documento in Post-print |  | Open Access Visualizza/Apri |
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