Deformable surface registration for breast tumors tracking: A phantom study

A phantom study for breast tumor registration based on the deformation of the external surface is proposed. This study aims at the integration into an image guided system for breast cancer biopsy or ablation. To compensate potentially large breast displacements, due to different positions of the breast during biopsy or ablation compared with preoperative data, where the diagnosis was made, an initial linear alignment using visible landmarks is involved, followed by thin-plate spline (TPS) registration of the linearly aligned surfaces. Subsequently, the TPS deformation will be applied to the tumors. The results were validated using a multi modal phantom of the breast, while the tumors and the surface were segmented on four different positions of the phantom: prone, supine, vertical and on a side. The use of computed tomography (CT) dataset allowed us to obtain a very precise segmentation of the external surface, of the tumors and the landmarks. Despite large variation among the different positions of the phantom due to the gravitational force, the accuracy of the method at the target point was under 5 millimeters. These results allow us to conclude that, using our prototype image registration system, we are able to align acquisition of the breast in different positions with clinically relevant accuracy.