The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study.
Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model
Carbognin, Luisa;Simbolo, Michele;Caliò, Anna;Vicentini, Caterina;Delfino, Pietro;Pilotto, Sara;Fiorio, Elena;Guarneri, Valentina;Conte, Pierfranco;Manfrin, Erminia;Brunelli, Matteo;Scarpa, Aldo;
2020-01-01
Abstract
The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study.
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