Psoriasis is a chronic immune-mediated inflammatory disease affecting 2-3% of Caucasian population. Several inflammatory mediators in patient samples have been associated with psoriasis and its comorbidities. Psoriasin (S100A7), a proinflammatory protein belonging to the S100 family of small calcium-binding proteins, is produced by epidermal keratinocytes and peripheral leukocytes and is significantly overexpressed in psoriasis.
Psoriasin (S100A7) is increased in serum of patients with moderate to severe psoriasis
Maurelli, M
;Gisondi, P;Danese, E;Gelati, M;Papagrigoraki, A;Del Giglio, M;Lippi, G;Girolomoni, G
2020-01-01
Abstract
Psoriasis is a chronic immune-mediated inflammatory disease affecting 2-3% of Caucasian population. Several inflammatory mediators in patient samples have been associated with psoriasis and its comorbidities. Psoriasin (S100A7), a proinflammatory protein belonging to the S100 family of small calcium-binding proteins, is produced by epidermal keratinocytes and peripheral leukocytes and is significantly overexpressed in psoriasis.
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